Santo Domingo is divided into 23 barangays:

1. Alimsog
2. Buhatan
3. Calayucay
4. Fidel Surtida
5. Lidong
6. Bagong San Roque
7. San Juan Pob. (Bgy. 2)
8. Santo Domingo Pob. (Bgy. 4)
9. San Pedro Pob. (Bgy. 5)
10. San Vicente Pob. (Bgy. 6)
11. San Rafael Pob. (Bgy. 7)
12. Del Rosario Pob. (Bgy. 3)
13. San Francisco Pob. (Bgy 1)
14. Nagsiya Pob. (Bgy. 8)
15. Salvacion
16. San Andres
17. San Fernando
18. San Isidro
19. San Roque
20. Santa Misericordia
21. Santo Niño
22. Market Site Pob. (Bgy. 9)
23. Pandayan Pob. (Bgy. 10)